Induction of Neuron-Specific Degradation of Coenzyme A Models Pantothenate Kinase-Associated Neurodegeneration by Reducing Motor Coordination in Mice.

Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized Stereo Tuner by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms.PanK initiates the synthesis of coenzyme A (CoA), an essential cofactor that plays a k

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