Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized Stereo Tuner by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms.PanK initiates the synthesis of coenzyme A (CoA), an essential cofactor that plays a k
Impact of Sample Type and DNA Isolation Procedure on Genomic Inference of Microbiome Composition
ABSTRACT Explorations of complex microbiomes using genomics greatly enhance our understanding about their diversity, biogeography, and function.The isolation of DNA from microbiome specimens is a key prerequisite for such examinations, but challenges remain in obtaining sufficient DNA quantities required for certain sequencing approaches, achieving
Carriage of upper respiratory tract pathogens in rural communities of Sarawak, Malaysian Borneo
Abstract Introduction Pneumonia is a leading cause of death in Malaysia.Whilst many studies have reported the aetiology of pneumonia in Western countries, the epidemiology of pneumonia in Malaysia remains poorly understood.As carriage is a prerequisite for disease, we sought to improve our understanding of the carriage and antimicrobial resistance
Response of interconnected estuarine lakes to sea-level rise and large hydrological structures
Study region: The Hii River basin, and Lakes Shinji and Nakaumi in Japan.Study focus: Womens Hoodies This study examines the impacts of sea-level rise (SLR) and hydrological structures on the salinity dynamics of Lakes Shinji and Nakaumi (SHINJI and NAKAUMI), two interconnected estuarine lakes in Japan.Over the past two decades, a significant upwar
Dialogue of Teenager with a Virtual Interlocutor as Mediation in the Development of Communicative Competence
The article describes a new methodological approach to formation of communicative competence of a teenager by means of dialogue with a virtual interlocutor.The possibilities of Stockings the development of communicative competence of a modern teenager using a software simulation of the dialogue, such as virtual interlocutors, and expert systems.Sho